He kakara dihydrocoumarin, e whakamahia ana i roto i te kai, e whakamahia ana hoki hei whakakapinga coumarin, hei kakara whakapaipai; he ranunga kirīmi, kokonati, he kakara hinamona; e whakamahia ana hoki hei kakara tupeka.
He paitini te dihydrocoumarin
Kāore te dihydrocoumarin i te paitini. He hua taiao te dihydrocoumarin e kitea ana i roto i ngā rāniora vanilla kōwhai. Ka hangaia mā te hauwai o te coumarin i te aroaro o te whakakorikori nikara i te 160-200 ℃ me raro i te pēhanga. Ka taea hoki te whakamahi hei rauemi mata, ka waikurahia ki roto i te wairewa kawakore hei whakaputa i te waikawa o-hydroxyphenylpropionic, ka maroke, ka whiwhi i te porowhita kati.
Āhua rokiroki
Kua kati, kua pōuri, kua rongoatia ki te wāhi hauhautanga, maroke hoki, kia iti rawa te wāhi i roto i te oko i raro i ngā whakaaetanga haumaru, ā, kua whakakiia ki te hauota tiaki. Rongoatia ki te whare putunga hauhautanga, hauhautanga. Kaua e pā ki te ahi, ki te wai. Me rongoa motuhake mai i te waikura, kaua e whakaranua te wāhi rokiroki. Kei roto ngā momo me te nui o ngā taputapu ahi e rite ana.
He rangahau i roto i te vitro
I roto i te whakamātautau whākōkī in vitro, i puta te aukati kukū-whakawhirinaki o te SIRT1 (IC50 o te 208μM) nā te dihydrocoumarin. I kitea te whakahekenga o te mahi deacetylase SIRT1 ahakoa i ngā horopeta micromolar (85±5.8 me te 73± 13.7% te mahi i te 1.6μM me te 8μM, ia). I aukatia hoki te deacetylase SIRT2 microtubule i roto i te tikanga rite-whakawhirinaki (IC50 o te 295μM).
I muri i te 24 hāora o te whakaaturanga, i whakanui ake te dihydrocoumarin (1-5mM) i te paitini pūtau i roto i ngā raina pūtau TK6 i runga i te horopeta e whakawhirinaki ana ki te horopeta. I whakanui ake te dihydrocoumarin (1-5mM) i te apoptosis i roto i ngā raina pūtau TK6 i runga i te horopeta e whakawhirinaki ana ki te horopeta i te wā 6-hāora. I whakanui ake te horopeta 5mM o te dihydrocoumarin i te apoptosis i te wā 6-hāora i roto i te raina pūtau TK6. I muri i te wā whakaaturanga 24-hāora, i whakanui ake te dihydrocoumarin (1-5mM) i te p53 lysine 373 me te 382 acetylation i runga i te horopeta e whakawhirinaki ana ki te horopeta i roto i te raina pūtau TK6.
Wā tuku: Whiringa-ā-rangi-01-2024