I mua i mōhiotia ko te "koura whakama", ā, ko tōna rongonui kei roto i tōna pānga whakama kore e taea te whakataurite i tetahi taha, me te uaua me te iti o tōna tangohanga i tetahi taha. Ko te tipu Glycyrrhiza glabra te pūtake o te Glabridin, engari ko te Glabridin anake te 0.1%-0.3% o tōna ihirangi katoa, arā, ko te 1000kg o te Glycyrrhiza glabra ka taea te whiwhi i te 100g oGlabridin, he ōrite te 1 karamu o Glabridin ki te 1 karamu o te koura tūturu.
He tohu noa a Hikarigandine i ngā kai otaota, ā, kua kitea tōna pānga mā i Hapani.
He tipu te Glycyrrhiza glabra nō te puninga Glycyrrhiza. Ko Haina te whenua he nui rawa ngā rauemi otaota o te ao, ā, neke atu i te 500 ngā momo otaota e whakamahia ana i roto i ngā mahi haumanu, ko te mea e whakamahia nuitia ana ko te rīkioriki. E ai ki ngā tatauranga, neke atu i te 79% te auau whakamahinga o te rīkioriki.
Nā te roa o te whakamahinga, me te rongonui nui hoki, kua whānui haere te whānuitanga o ngā rangahau mō te uara o te rīkiora, ā, kua whānui haere hoki te whakamahinga. E ai ki ngā rangahau, he nui te whakaute o ngā kaihoko i Āhia, inā koa i Hapani, ki ngā mea whakapaipai kei roto ngā matū hohe o te otaota. E 114 ngā matū whakapaipai otaota kua tuhia ki roto i te "Japan's General Cosmetics Raw Materials", ā, kua 200 ngā momo mea whakapaipai kei roto ngā matū otaota i Hapani.
E mōhiotia ana he tino kaha tōna pānga ki te mā, engari he aha ngā uauatanga o te whakamahinga?
Kei roto i te wāhanga hydrophobic o te tangohanga raiki he momo flavonoids. Hei wāhanga matua o tōna wāhanga hydrophobic, he pānga aukati tō te halo-glycyrrhizidine ki te hanga melanin, ā, he pānga ārai-mumura me te ārai-waikura anō hoki.
E whakaatu ana ētahi raraunga whakamātautau ko te pānga mā o te Glabridin māmā he 232 ngā wā teitei ake i te huaora C noa, 16 ngā wā teitei ake i te hydroquinone, ā, 1,164 ngā wā teitei ake i te arbutin. Mō te whakatutuki i te mahi mā kaha ake, e toru ngā huarahi e homai ana e te Glabridin māmā.
1. Te aukati i te mahi tyrosinase
Ko te tikanga matua mō te mā oGlabridinKo te kaupapa matua he aukati i te hanganga o te melanin mā te whakataetae aukati i te mahi tyrosinase, ka tangohia tetahi wāhanga o te tyrosinase mai i te mowhiti whakatere o te hanganga melanin, ā, ka ārai i te here o te matū ki te tyrosinase.
2. Pānga ārai mate
Ka taea e ia te aukati i te mahi a te tyrosinase me te dopa pigment interchange me te mahi a te dihydroxyindole carboxylic acid oxidase.
Kua whakaaturia mai i te kukū o te 0.1mg/ml, ka taea e te photoglycyrrhizidine te mahi ki te pūnaha whakapūngao cytochrome P450/NADOH me te tango i te 67% o ngā rauropi kore utu, he kaha te mahi ārai mate.
3. Ārai i ngā āhuatanga mumura me te whawhai ki te UV
I tēnei wā, he iti ake ngā rangahau kua pūrongohia mō te whakamahinga o te photoglycyrrhizidine i roto i te rangahau mō te koroheketanga kiri i puta mai i te hihi UV. I te tau 2021, i roto i tētahi tuhinga i roto i te puka matua o te Journal of Microbiology and Biotechnology, i rangahauhia ngā liposome photoglycyrrhizidine mō tō rātou kaha ki te whakapai ake i te whero me te mate kiri i puta mai i te hihi UV mā te aukati i ngā āhuatanga mumura. Ka taea te whakamahi i ngā liposome photoglycyrrhizidine hei whakapai ake i te bioavailability me te iti ake o te cytotoxicity me te aukati pai ake i te melanin, me te whakaiti i te whakaaturanga o ngā cytokines mumura, interleukin 6 me te interleukin 10. Nō reira, ka taea te whakamahi hei rongoā ā-papa hei ārai i te kino o te kiri i puta mai i te hihi UV mā te aukati i te mumura, ka whakarato pea i ētahi whakaaro mō te rangahau i ngā hua tiaki whakama i te rā.
Hei whakarāpopototanga, e mōhiotia ana te pānga mā o te photoglycyrrhizidine, engari ko tōna āhua ake he mea tata kore e wairewa i roto i te wai, nō reira he mea tino uaua mō te tukanga whakaputa me te hanga i roto i te tono tāpiri hua tiaki kiri, ā, he otinga pai i tēnei wā mā te hangarau whakakī liposome. Heoi anō, ko te photoGlabridinKa taea e ngā liposome te aukati i te koroheketanga whakaahua i puta mai i te UV, engari me nui ake ngā whakamātautau haumanu hei whakaū i tēnei mahi, me te whakatinana i ngā tono rangahau.
Ngā hua tiaki kiri kei roto ko te photoGlabridin i te ahua o te whakakotahitanga o ngā kai.
Ahakoa kāore e kore he tino pai te pānga mā o te photoGlabridine, he tino utu nui hoki te utu o ngā rauemi mata nā te uaua o te tango me te ihirangi. I roto i te R&D whakapaipai, ko te mahi whakahaere utu e hono tika ana ki te ihirangi hangarau me te tukanga pūtaiao. Nō reira, he huarahi pai ki te whakahaere i te utu o ngā whakatakotoranga me te whakatutuki i te kounga haumaru me te whai hua mā te whiriwhiri i ngā kai hohe me te whakakotahi i a rātou ki te whakakotahi me te photoglycyrrhizidine. Hei tāpiritanga ki te taumata R&D, me rapu atu i ngā rangahau mō ngā liposome photoglycyrrhizidine me ngā tikanga tango hou.
Wā tuku: 30 o Ākuhata 2022